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Perspective of Use of Antiviral Peptides against Influenza Virus
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SYSNO ASEP 0457799 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Perspective of Use of Antiviral Peptides against Influenza Virus Tvůrce(i) Skaličková, S. (CZ)
Heger, Z. (CZ)
Krejčová, L. (CZ)
Pekárik, V. (CZ)
Bastl, K. (CZ)
Janda, Jozef (UZFG-Y) RID
Kostolanský, F. (SK)
Varečková, E. (SK)
Zítka, O. (CZ)
Adam, V. (CZ)
Kizek, R. (CZ)Zdroj.dok. Viruses. - : MDPI
Roč. 7, č. 10 (2015), s. 5428-5442Poč.str. 15 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova cationic peptides ; hemagglutinin ; influenza virus Vědní obor RIV EE - Mikrobiologie, virologie CEP ED2.1.00/03.0124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000364242200017 EID SCOPUS 84944901079 DOI 10.3390/v7102883 Anotace The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs requires urgent development of new strategies for antiviral therapy, too. The research in the field of therapeutic peptides began to develop extensively in the second half of the 20(th) century. Since then, the mechanisms of action for several peptides and their antiviral prospect received large attention due to the global threat posed by viruses. Here, we discussed the therapeutic properties of peptides used in influenza treatment. Peptides with antiviral activity against influenza can be divided into three main groups. First, entry blocker peptides such as a Flupep that interact with influenza hemagglutinin, block its binding to host cells and prevent viral fusion. Second, several peptides display virucidal activity, disrupting viral envelopes, e.g., Melittin. Finally, a third set of peptides interacts with the viral polymerase complex and act as viral replication inhibitors such as PB1 derived peptides. Here, we present a review of the current literature describing the antiviral activity, mechanism and future therapeutic potential of these influenza antiviral peptides. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2016
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