Počet záznamů: 1
In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions
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SYSNO ASEP 0457461 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV D - Článek ve sborníku Název In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions Tvůrce(i) Tian, F. (US)
Min, J. (US)
Kaňka, Jiří (URE-Y)
Hammond, P. T. (US)
Du, H. (US)Zdroj.dok. Proceedings of SPIE - FIBER OPTIC SENSORS AND APPLICATIONS XII, 9480. - Washington : SPIE, 2015 / Udd Erick ; Pickrell Gary ; Du H. Henry - ISSN 0277-786X - ISBN 978-1-62841-596-4 Rozsah stran s. 9480051-9480059 Poč.str. 9 s. Forma vydání Tištěná - P Akce Conference on Fiber Optic Sensors and Applications XII Datum konání 22.04.2015 - 23.04.2015 Místo konání Baltimore Země US - Spojené státy americké Typ akce WRD Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova long period grating ; drug release ; polyelectrolyte Vědní obor RIV JA - Elektronika a optoelektronika, elektrotechnika CEP LH11038 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora URE-Y - RVO:67985882 UT WOS 000357019100004 EID SCOPUS 84948823609 DOI 10.1117/12.2191683 Anotace The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy Pracoviště Ústav fotoniky a elektroniky Kontakt Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Rok sběru 2016
Počet záznamů: 1