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Multiple Cross-Species Transmission Events of Human/nAdenoviruses (HAdV) during Hominine Evolution
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SYSNO ASEP 0453367 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Multiple Cross-Species Transmission Events of Human/nAdenoviruses (HAdV) during Hominine Evolution Tvůrce(i) Hoppe, E. (DE)
Pauly, M. (DE)
Gillespie, T. R. (US)
Akoua-Koffi, C. (CI)
Hohmann, G. (DE)
Fruth, B. (DE)
Karhemere, S. (CG)
Madinda, N. F. (DE)
Mugisha, L. (UG)
Muyembe, J.-J. (CG)
Todd, A. (CF)
Petrželková, Klára Judita (BC-A) RID
Gray, M. (RW)
Robbins, M. (DE)
Bergl, R. A. (US)
Wittig, R. M. (DE)
Zuberbühler, K. (CH)
Boesch, C. (DE)
Schubert, G. (DE)
Leendertz, F. H. (DE)
Ehlers, B. (DE)
Calvignac-Spencer, S. (DE)Zdroj.dok. Molecular Biology and Evolution. - : Oxford University Press - ISSN 0737-4038
Roč. 32, č. 8 (2015), s. 2072-2084Poč.str. 13 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adenovirus ; African great apes ; zoonosis Vědní obor RIV GJ - Choroby a škůdci zvířat, veterinární medicína CEP GA206/09/0927 GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000360586500013 DOI 10.1093/molbev/msv090 Anotace Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare along HAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat and dietary overlap may lead to fecal-oral cross-hominine transmission of HAdV. Finally, we determined that two independent HAdV-B transmission events to humans occurred more than 100,000 years ago. We conclude that HAdV-B circulating in humans are of zoonotic origin and have probably affected global human health for most of our species lifetime. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2016
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