Počet záznamů: 1
Telomere Length in Circulating Lymphocytes: Association with Chromosomal Aberrations
- 1.
SYSNO ASEP 0452273 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Telomere Length in Circulating Lymphocytes: Association with Chromosomal Aberrations Tvůrce(i) Hemminki, K. (DE)
Rachakonda, S. (DE)
Musak, L. (SK)
Vymetálková, Veronika (UEM-P) RID
Halasová, E. (SK)
Forsti,, A. (DE)
Vodičková, Ludmila (UEM-P) RID
Buchancová, J. (SK)
Vodička, Pavel (UEM-P) RID
Kumar, R. (DE)Celkový počet autorů 10 Zdroj.dok. Genes Chromosomes & Cancer. - : Wiley - ISSN 1045-2257
Roč. 54, č. 3 (2015), s. 194-196Poč.str. 3 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova structural chromosome aberrations ; healthy subjects ; relative telomere length ; genotoxicity ; telomere biology Vědní obor RIV EB - Genetika a molekulární biologie Institucionální podpora UEM-P - RVO:68378041 UT WOS 000348577000007 EID SCOPUS 84921460776 DOI 10.1002/gcc.22225 Anotace Nonspecific chromosomal aberrations (CAs) are analyzed by microscopic scoring of metaphase nuclei and they include fragmented, missing, or fused chromosomal segments which may not be clonally expanded but remain in lymphocytes for their life-time. CAs are a marker of cancer risk and many specific CAs are believed to be causative events in malignant transformation. However, it has recently been realized that, instead of direct DNA damage, mechanisms associated with telomere biology are important contributors to formation of CAs, preferentially of CSA type. In this study, we measured relative telomere length (RTL) in lymphocytes of healthy volunteers whose CAs have been quantified and classified as either CSA or CTA. The median RTL was 1.28 for 48 subjects showing no CAs, and 1.19 for 47 individuals with a total of more than 2 CAs (P=0.03). Further decreased median RTL (1.12) was recorded in 68 individuals with CSAs (P=0.001). These results, together with similar data by Li et al. (2013), provide strong evidence that telomere biology contributes to CA formation, particularly of the CSA type, in healthy individuals and that direct genotoxic mechanisms are not the only causal pathways. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2016
Počet záznamů: 1