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Altered intensity coding in the salicylate-overdose animal model of tinnitus
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SYSNO ASEP 0452139 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Altered intensity coding in the salicylate-overdose animal model of tinnitus Tvůrce(i) Wan, I. (TW)
Pokora, O. (CZ)
Chiu, T. (TW)
Lánský, Petr (FGU-C) RID, ORCID
Poon, P. W. (TW)Zdroj.dok. Biosystems. - : Elsevier - ISSN 0303-2647
Roč. 136, Oct 2015 (2015), s. 113-119Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova auditory evoked potential ; electrocorticogram ; Fisher information ; salicylate-overdose ; tinnitus ; rat Vědní obor RIV BD - Teorie informace CEP GA15-08066S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000366535200014 EID SCOPUS 84949085365 DOI 10.1016/j.biosystems.2015.06.010 Anotace Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2016
Počet záznamů: 1