Počet záznamů: 1
Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems
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SYSNO ASEP 0451957 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems Tvůrce(i) Kašparová, D. (CZ)
Neckář, Jan (FGU-C) RID, ORCID
Dabrowská, L. (CZ)
Novotný, J. (CZ)
Mráz, J. (CZ)
Kolář, František (FGU-C) RID, ORCID, SAI
Žurmanová, J. (CZ)Zdroj.dok. Physiological Genomics. - : American Physiological Society - ISSN 1094-8341
Roč. 47, č. 12 (2015), s. 612-620Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adaptation to hypoxia ; cardioprotection ; ischemia-reperfusion injury ; oxidative stress ; antioxidant defense Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie CEP GAP303/12/1162 GA ČR - Grantová agentura ČR GA13-10267S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000365900400004 EID SCOPUS 84951271981 DOI 10.1152/physiolgenomics.00058.2015 Anotace It this study we investigated the relationship between myocardial tolerance to ischemia/reperfusion injury and transcription activity of major antioxidant genes, transcription factors, and oxidative stress in three different regimens of chronic hypoxia. Adult male Wistar rats were exposed to continuous normobaric hypoxia either continuously (CNH) or intermittently for 8 h/day (INH8) or 23 h/day (INH23) for 3 wk period. Whereas CNH as well as INH8 decreased infarct size, 1 h daily reoxygenation (INH23) abolished the cardioprotective effect. The majority of mRNAs of antioxidant genes related to mitochondrial antioxidant defense were upregulated in both cardioprotective regimens but not in INH23 rats. Our results suggest that the increased mitochondrial antioxidant defense plays an important role in cardioprotection afforded by chronic hypoxia Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2016
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