Počet záznamů: 1
Human multipotent mesenchymal stromal cells in the treatment of postoperative temporal bone defect: an animal model
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SYSNO ASEP 0450151 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Human multipotent mesenchymal stromal cells in the treatment of postoperative temporal bone defect: an animal model Tvůrce(i) Školoudík, L. (CZ)
Chrobok, V. (CZ)
Kalfert, D. (CZ)
Kočí, Zuzana (UEM-P)
Syková, Eva (UEM-P) RID
Chumak, Tetyana (UEM-P)
Popelář, Jiří (UEM-P) RID
Syka, Josef (UEM-P) RID
Laco, J. (CZ)
Dědková, J. (CZ)
Dayanithi, Govindan (UEM-P) RID
Filip, S. (CZ)Celkový počet autorů 12 Zdroj.dok. Cell Transplantation. - : Sage - ISSN 0963-6897
Roč. 25, č. 7 (2016), s. 1405-1414Poč.str. 28 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Human bone marrow ; Human mesenchymal stromal cells (hMSCs) ; Middle ear surgery ; Temporal bone Vědní obor RIV FP - Ostatní lékařské obory CEP LO1309 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEM-P - RVO:68378041 UT WOS 000384801200017 EID SCOPUS 84978134221 DOI 10.3727/096368915X689730 Anotace Canal wall down mastoidectomy is one of the most effective treatments for cholesteatoma. However, it results in anatomical changes in the external and middle ear with a negative impact on the patient's quality of life. To provide complete closure of the mastoid cavity and normalize the anatomy of the middle and external ear, we used human multipotent mesenchymal stromal cells (hMSCs), GMP grade, in a guinea pig model. A method for preparing a biomaterial composed of hMSCs, hydroxyapatite, and tissue glue was developed. Animals from the treated group were implanted with biomaterial composed of hydroxyapatite and hMSCs, while animals in the control group received hydroxyapatite alone. When compared to controls, the group implanted with hMSCs showed a significantly higher ratio of new bone formation (p = 0.00174), as well as a significantly higher volume percentage of new immature bone (p = 0.00166). Our results proved a beneficial effect of hMSCs on temporal bone formation and provided a promising tool to improve the quality of life of patients after canal wall down mastoidectomy by hMSC implantation. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
Počet záznamů: 1