Počet záznamů: 1
Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth
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SYSNO ASEP 0448644 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth Tvůrce(i) Jäger, Eliezer (UMCH-V) ORCID, RID
Donato, R. K. (BR)
Perchacz, Magdalena (UMCH-V) RID
Jäger, Alessandro (UMCH-V) RID, ORCID
Surman, František (UMCH-V)
Höcherl, Anita (UMCH-V) RID
Konefal, Rafal (UMCH-V) RID, ORCID
Donato, K. Z. (BR)
Venturini, Cristina Garcia (UMCH-V)
Bergamo, V. Z. (BR)
Schrekker, H. S. (BR)
Fuentefria, A. M. (BR)
Raucci, M. G. (IT)
Ambrosio, L. (IT)
Štěpánek, Petr (UMCH-V) RID, ORCIDZdroj.dok. RSC Advances. - : Royal Society of Chemistry
Roč. 5, č. 104 (2015), s. 85756-85766Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polyesters ; coating of medical devices ; fungal biofilm inhibition Vědní obor RIV EE - Mikrobiologie, virologie CEP 7F14009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy FR-TI4/625 GA MPO - Ministerstvo průmyslu a obchodu Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000363179900071 EID SCOPUS 84944789828 DOI 10.1039/C5RA15858C Anotace Herein, we present the intrinsic property of well-known polyesters [poly(alkene succinates)], as Candida albicans and Candida tropicalis biofilm inhibitors with potential to substantially reduce the incidence of device-associated infections in, e.g., indwelling catheters and sutures. These new biopolymer applications, either for manufacturing or coating medical devices, present innovative features such as: simple and cheap preparation, easy scaling-up, good mechanical and thermal resistance properties, and antibiofilm ability without any specific surface functionalization or antimicrobial agent encapsulation. Furthermore, the polyesters are shown to be highly biocompatible, promote human mesenchymal stem cell (hMSC) attachment and proliferation, inducing morphological changes, which are dependent on the polymer structural characteristics, making them promising candidates for materials in specialized medical devices and in the tissue engineering field. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2016
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