Počet záznamů: 1  

Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

  1. 1.
    SYSNO ASEP0448089
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevSterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines
    Tvůrce(i) Chen, Y. (CN)
    Angelova, A. (FR)
    Angelov, Borislav (UMCH-V) RID
    Drechsler, M. (DE)
    Garamus, V. M. (DE)
    Willumeit-Römer, R. (DE)
    Zou, A. (CN)
    Zdroj.dok.Journal of Materials Chemistry B - ISSN 2050-750X
    Roč. 3, č. 39 (2015), s. 7734-7744
    Poč.str.11 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaSAXS ; soft matter ; nanoparticles
    Vědní obor RIVCF - Fyzikální chemie a teoretická chemie
    CEPGC15-10527J GA ČR - Grantová agentura ČR
    Institucionální podporaUMCH-V - RVO:61389013
    UT WOS000362350600011
    EID SCOPUS84942852277
    DOI10.1039/C5TB01193K
    AnotaceMultidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2016
Počet záznamů: 1  

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