Počet záznamů: 1

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

SYSNO ASEP	0446227
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Tvůrce(i)	Goodson, W.H. (US) Vondráček, Jan (BFU-R)_{RID, ORCID}
Celkový počet autorů	147
Zdroj.dok.	Carcinogenesis. - : Oxford University Press - ISSN 0143-3334 Roč. 36, JUN 2015 (2015), s. 254-296
Poč.str.	43 s.
Forma vydání	Tištěná - P
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	BREAST-CANCER CELLS ; ESTROGEN-RECEPTOR-ALPHA ; EPITHELIAL-MESENCHYMAL TRANSITION
Vědní obor RIV	BO - Biofyzika
CEP	GA13-07711S GA ČR - Grantová agentura ČR
UT WOS	000357048100013
DOI	10.1093/carcin/bgv039
Anotace	Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis.
Pracoviště	Biofyzikální ústav
Kontakt	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Rok sběru	2016

Počet záznamů: 1