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The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women
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SYSNO ASEP 0445120 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women Tvůrce(i) Mrizak, I. (TN)
Šerý, Omar (UZFG-Y) RID
Plesník, J. (CZ)
Arfa, A. (TN)
Fekih, M. (TN)
Bouslema, A. (TN)
Zaouali, M. (TN)
Tabka, Z. (TN)
Khan, N. A. (FR)Zdroj.dok. British Journal of Nutrition. - : Cambridge University Press - ISSN 0007-1145
Roč. 113, č. 8 (2015), s. 1330-1337Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova obesity ; lipids ; taste ; genes Vědní obor RIV ED - Fyziologie Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000354055400016 EID SCOPUS 84929497910 DOI 10.1017/S0007114515000343 Anotace Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-alpha (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-alpha gene polymorphisms. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2016
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