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Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy
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SYSNO ASEP 0444484 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy Tvůrce(i) Dong, L.F. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Progress in Molecular Biology and Translational Science - ISSN 1877-1173
Roč. 2014, č. 127 (2014), s. 211-227Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ALPHA-TOCOPHERYL SUCCINATE ; RESPIRATORY COMPLEX-II ; DNA MUTATIONS Vědní obor RIV EB - Genetika a molekulární biologie Institucionální podpora BTO-N - RVO:86652036 UT WOS 000341461400008 DOI 10.1016/B978-0-12-394625-6.00008-8 Anotace Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2016
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