Počet záznamů: 1
Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
- 1.
SYSNO ASEP 0440852 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA Tvůrce(i) Tan, A.S. (NZ)
Dong, L.F. (AU)
Bezawork-Geleta, A. (AU)
Endaya, B. (AU)
Goodwin, J. (AU)
Bajziková, Martina (BTO-N) RID
Kovářová, Jaromíra (BTO-N) RID
Peterka, Martin (BTO-N)
Yan, B. (AU)
Alizadeh Pesdar, E. (AU)
Sobol, Margaryta (UMG-J) RID
Filimonenko, Anatolij (UMG-J)
Stuart, S. (AU)
Vondrusová, Magdaléna (BTO-N) RID
Klučková, Katarína (BTO-N) RID
Sachaphibulkij, K. (AU)
Rohlena, Jakub (BTO-N) RID, ORCID
Hozák, Pavel (UMG-J) RID, ORCID
Truksa, Jaroslav (BTO-N) RID, ORCID
Eccles, D. (AU)
Haupt, D. (AU)
Griffiths, L.R. (AU)
Neužil, Jiří (BTO-N) RID
Berridge, M.V. (AU)Zdroj.dok. Cell Metabolism. - : Cell Press - ISSN 1550-4131
Roč. 21, č. 1 (2015), s. 81-94Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ELECTRON-TRANSPORT CHAIN ; MAMMALIAN MITOCHONDRIA ; TUNNELING NANOTUBES Vědní obor RIV EB - Genetika a molekulární biologie CEP ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GAP301/10/1937 GA ČR - Grantová agentura ČR GA15-02203S GA ČR - Grantová agentura ČR GAP305/12/1708 GA ČR - Grantová agentura ČR GAP301/12/1851 GA ČR - Grantová agentura ČR Institucionální podpora BTO-N - RVO:86652036 ; UMG-J - RVO:68378050 UT WOS 000347467900012 DOI 10.1016/j.cmet.2014.12.003 Anotace We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells. This leads to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth. Cell lines from circulating tumor cells showed further recovery of mitochondrial respiration and an intermediate lag to tumor growth, while cells from lung metastases exhibited full restoration of respiratory function and no lag in tumor growth. Stepwise assembly of mitochondrial respiratory (super)complexes was correlated with acquisition of respiratory function. Our findings indicate horizontal transfer of mtDNA from host cells in the tumor microenvironment to tumor cells with compromised respiratory function to re-establish respiration and tumor-initiating efficacy. These results suggest pathophysiological processes for overcoming mtDNA damage and support the notion of high plasticity of malignant cells. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2015
Počet záznamů: 1