Počet záznamů: 1
Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines
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SYSNO ASEP 0439957 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines Tvůrce(i) Šebo, Peter (MBU-M) RID, ORCID
Osička, Radim (MBU-M) RID, ORCID
Mašín, Jiří (MBU-M) RID, ORCIDCelkový počet autorů 3 Zdroj.dok. Expert Review of Vaccines - ISSN 1476-0584
Roč. 13, č. 10 (2014), s. 1215-1227Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova adenylate cyclase toxin ; antigen delivery ; Bordetella pertussis Vědní obor RIV EE - Mikrobiologie, virologie CEP GA13-14547S GA ČR - Grantová agentura ČR GAP302/11/0580 GA ČR - Grantová agentura ČR GAP302/12/0460 GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000342073300008 Anotace The adenylate cyclase toxin-hemolysin (ACT, AC-Hly or CyaA) is a key virulence factor of Bordetella pertussis. It targets bactericidal activities of phagocytes, such as oxidative burst and complement- or antibody-mediated opsonophagocytic killing of bacteria. Through cAMP signaling, CyaA also skews TLR-triggered maturation of dendritic cells, inhibiting proinflammatory IL-12 and TNF- secretion and enhancing IL-10 production and Treg expansion, likely hampering induction of adaptive immune responses to Bordetella infections. Non-enzymatic CyaA toxoid is a potent protective antigen and adjuvant that boosts immunogenicity of co-administered B. pertussis antigens and improves potency of acellular pertussis (aP) vaccines in mice. This makes CyaA a prime antigen candidate for inclusion into a next generation of aP vaccines. Moreover, recombinant CyaA toxoids were recently shown to be safe in humans in frame of Phase I clinical evaluation of a CyaA-based immunotherapeutic vaccine that induces Th1-polarized CD8(+) cytotoxic T-lymphocyte responses targeting cervical tumors. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2015
Počet záznamů: 1