Počet záznamů: 1  

Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines

  1. 1.
    SYSNO ASEP0439957
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAdenylate cyclase toxin-hemolysin relevance for pertussis vaccines
    Tvůrce(i) Šebo, Peter (MBU-M) RID
    Osička, Radim (MBU-M) RID
    Mašín, Jiří (MBU-M) RID
    Celkový počet autorů3
    Zdroj.dok.Expert Review of Vaccines - ISSN 1476-0584
    Roč. 13, č. 10 (2014), s. 1215-1227
    Poč.str.13 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaadenylate cyclase toxin ; antigen delivery ; Bordetella pertussis
    Vědní obor RIVEE - Mikrobiologie, virologie
    CEPGA13-14547S GA ČR - Grantová agentura ČR
    GAP302/11/0580 GA ČR - Grantová agentura ČR
    GAP302/12/0460 GA ČR - Grantová agentura ČR
    Institucionální podporaMBU-M - RVO:61388971
    UT WOS000342073300008
    AnotaceThe adenylate cyclase toxin-hemolysin (ACT, AC-Hly or CyaA) is a key virulence factor of Bordetella pertussis. It targets bactericidal activities of phagocytes, such as oxidative burst and complement- or antibody-mediated opsonophagocytic killing of bacteria. Through cAMP signaling, CyaA also skews TLR-triggered maturation of dendritic cells, inhibiting proinflammatory IL-12 and TNF- secretion and enhancing IL-10 production and Treg expansion, likely hampering induction of adaptive immune responses to Bordetella infections. Non-enzymatic CyaA toxoid is a potent protective antigen and adjuvant that boosts immunogenicity of co-administered B. pertussis antigens and improves potency of acellular pertussis (aP) vaccines in mice. This makes CyaA a prime antigen candidate for inclusion into a next generation of aP vaccines. Moreover, recombinant CyaA toxoids were recently shown to be safe in humans in frame of Phase I clinical evaluation of a CyaA-based immunotherapeutic vaccine that induces Th1-polarized CD8(+) cytotoxic T-lymphocyte responses targeting cervical tumors.
    PracovištěMikrobiologický ústav
    KontaktEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Rok sběru2015