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A thermodynamic model of bone remodelling: The influence of dynamic loading together with biochemical control
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SYSNO ASEP 0438609 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A thermodynamic model of bone remodelling: The influence of dynamic loading together with biochemical control Tvůrce(i) Klika, Václav (UT-L) RID
Maršík, František (UT-L) RIDZdroj.dok. Journal of Musculoskeletal Interactions - ISSN 1108-7161
Roč. 10, č. 3 (2010), s. 220-230Poč.str. 11 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GR - Řecko Klíč. slova bone remodelling ; chemical kinetics ; dynamic loading Vědní obor RIV FI - Traumatologie, ortopedie CEP GA106/08/0557 GA ČR - Grantová agentura ČR CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000282051300005 EID SCOPUS 77957330175 Anotace Understanding of the bone remodelling process has considerably increased during the last 20 years. Since the ability to simulate (and predict) the effects of bone remodelling offers substantial insights, several models have been proposed to describe this phenomenon. The strength of the presented model is that it includes biochemical control factors (e.g., the necessity of cell-to-cell contact, which is mediated by the RANKL-RANK-OPG chain during osteoclastogenesis) and mechanical stimulation, the governing equations are derived from interaction kinetics (e.g., mass is preserved in running reactions), and the parameters are measurable. Behaviour of the model is in accordance with experimental and clinical observations, such as the role of dynamic loading, the inhibitory effect of dynamic loading on osteoclastogenesis, the observation that polykaryon osteoclasts are activated and formed by a direct cell-to-cell contact, and the correct concentrations of osteoblasts, osteoclasts, and osteocytes. The model does not yet describe the bone remodelling process in complete detail, but the implemented simplifications describe the key features and further details of control mechanisms may be added. Pracoviště Ústav termomechaniky Kontakt Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Rok sběru 2015
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