Počet záznamů: 1  

Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

  1. 1.
    SYSNO ASEP0428048
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevContribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
    Tvůrce(i) Líšková, Silvia (FGU-C)
    Petrová, M. (SK)
    Karen, Petr (FGU-C)
    Behuliak, Michal (FGU-C) RID
    Zicha, Josef (FGU-C) RID
    Zdroj.dok.BioMed Research International - ISSN 2314-6133
    Roč. 2014, č. 2014 (2014), s. 289361
    Poč.str.9 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovacalcium-dependent chloride channels ; endothelium-derived contracting factor ; ageing
    Vědní obor RIVFA - Kardiovaskulární nemoci vč. kardiochirurgie
    CEPGAP304/12/0259 GA ČR - Grantová agentura ČR
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000332565500001
    EID SCOPUS84897882006
    DOI10.1155/2014/289361
    AnotaceThe activation of calcium-dependent chloride channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase calcium entry. Hypertension and ageing are associated with altered calcium handling including possible activation of calcium-dependent chloride channels. Our study was aimed to determine calcium -dependent chloride channels contribution to norepinephrine-induced contraction during hypertension and ageing. We have found that contribution of calcium -dependent chloride channels to norepinephrine-induced contraction diminished with age, hypertension development, and/or NO synthesis inhibition
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2015