Počet záznamů: 1

Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist

SYSNO ASEP	0427937
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist
Tvůrce(i)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Komůrková, Denisa (BFU-R)_{RID, ORCID}
Celkový počet autorů	5
Zdroj.dok.	Central European Journal of Biology - ISSN 1895-104X Roč. 9, č. 6 (2014), s. 642-646
Poč.str.	5 s.
Forma vydání	Tištěná - P
Jazyk dok.	eng - angličtina
Země vyd.	PL - Polsko
Klíč. slova	Hematopoiesis ; Cyclooxygenase inhibition ; Adenosine receptor agonist
Vědní obor RIV	BO - Biofyzika
CEP	GAP303/11/0128 GA ČR - Grantová agentura ČR
Institucionální podpora	BFU-R - RVO:68081707
UT WOS	000333127400005
DOI	10.2478/s11535-014-0295-0
Anotace	Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our studies on post-exposure treatment of mice irradiated by sublethal or lethal doses of ionizing radiation included testing the effectiveness of meloxicam, a cyclooxygenase-2 inhibitor, and IB-MECA, an adenosine A3 receptor agonist. The efficacy of meloxicam and IB-MECA to positively influence the progress of the acute radiation disease has been tested in situations of their combined administration with granulocyte colony-stimulating factor (G-CSF) or with each other. The results of our studies revealed a significantly improved regeneration of hematopoietic cell populations ranging from the bone marrow progenitor cells to mature blood cells following combined treatments. Also, survival of mice exposed to lethal radiation doses was highest in the animals treated with a combination of the two drugs.
Pracoviště	Biofyzikální ústav
Kontakt	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Rok sběru	2015

Počet záznamů: 1