Počet záznamů: 1
Comprehensive portrait of cholesterol containing oxidized membrane
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SYSNO ASEP 0427792 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Comprehensive portrait of cholesterol containing oxidized membrane Tvůrce(i) Štefl, Martin (UFCH-W)
Šachl, Radek (UFCH-W) RID, ORCID
Olžyńska, Agnieszka (UFCH-W) RID
Amaro, Mariana (UFCH-W) RID, ORCID
Savchenko, Dariia (FZU-D) RID, ORCID
Deyneka, Alexander (FZU-D)
Hermetter, A. (AT)
Cwiklik, Lukasz (UFCH-W) RID, ORCID
Humpolíčková, Jana (UFCH-W) RID
Hof, Martin (UFCH-W) RID, ORCIDZdroj.dok. Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736
Roč. 1838, č. 7 (2014), s. 1769-1776Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova oxidized lipids ; lateral diffusion ; molecular dynamics simulations Vědní obor RIV CF - Fyzikální chemie a teoretická chemie CEP GBP208/12/G016 GA ČR - Grantová agentura ČR LH13259 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UFCH-W - RVO:61388955 ; FZU-D - RVO:68378271 UT WOS 000336695300009 EID SCOPUS 84899037032 DOI https://doi.org/10.1016/j.bbamem.2014.02.006 Anotace Biologicalmembranes are under significant oxidative stress caused by reactive oxygen species mostly originating during cellular respiration. Double bonds of the unsaturated lipids are most prone to oxidation,which might lead to shortening of the oxidized chain and inserting of terminal either aldehyde or carboxylic group. Structural rearrangement of oxidized lipids, addressed already, is mainly associated with looping back of the hydrophilic terminal group. This contribution utilizing dual-focus fluorescence correlation spectroscopy and electron paramagnetic resonance as well as atomistic molecular dynamics simulations focuses on the overall changes of the membrane structural and dynamical properties once it becomes oxidized. Particularly, attention is paid to cholesterol rearrangement in the oxidized membrane revealing its preferable interaction with carbonyls of the oxidized chains. In this view cholesterol seems to have a tendency to repair, rather than condense, the bilayer. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2015
Počet záznamů: 1