Počet záznamů: 1

First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

SYSNO ASEP	0427348
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds
Tvůrce(i)	Bainová, H. (CZ) Králová, Tereza (UBO-W)_ORCID Bryjová, Anna (UBO-W)_{SAI, ORCID} Albrecht, Tomáš (UBO-W)_{RID, SAI, ORCID} Bryja, Josef (UBO-W)_{RID, SAI, ORCID} Vinkler, M. (CZ)
Celkový počet autorů	6
Zdroj.dok.	Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X Roč. 45, č. 1 (2014), s. 151-155
Poč.str.	5 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	Birds ; Expression ; Innate immunity ; Toll-like receptor 5 ; Pseudogene ; Flagellin
Vědní obor RIV	EG - Zoologie
CEP	GAP505/10/1871 GA ČR - Grantová agentura ČR
Institucionální podpora	UBO-W - RVO:68081766
UT WOS	000335624800016
EID SCOPUS	84896444800
DOI	10.1016/j.dci.2014.02.010
Anotace	Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Aves: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds.
Pracoviště	Ústav biologie obratlovců
Kontakt	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Rok sběru	2015

Počet záznamů: 1