Počet záznamů: 1
Generating different genetic expression patterns in the early embryo: insights from the mouse model
- 1.
SYSNO ASEP 0425926 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Generating different genetic expression patterns in the early embryo: insights from the mouse model Tvůrce(i) Bruce, Alexander (BC-A) RID Zdroj.dok. Reproductive BioMedicine Online - ISSN 1472-6483
Roč. 27, č. 6 (2013), s. 586-592Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cell fate ; preimplantation embryo ; probabilistic Vědní obor RIV EB - Genetika a molekulární biologie Institucionální podpora BC-A - RVO:60077344 UT WOS 000328079400003 EID SCOPUS 84889083553 DOI 10.1016/j.rbmo.2013.03.024 Anotace The divergence of two differentiating extraembryonic cell types (trophectoderm and primitive endoderm) from the pluripotent epiblast population (the source of fetal progenitor cells) by the blastocyst stage of mouse development relies upon the activation and execution of lineage-specific gene expression programmes. While our understanding of the central transcription factor 'effectors' directing these cell-fate choices has accumulated rapidly, what is less clear is how the differential expression of such genes within the diverging lineages is initially generated. This review summarizes and consolidates current understanding. I introduce the traditional concept and importance of a cell's spatial location within the embryo, referencing recent mechanistic and molecular insights relating to cell fate. Additionally, I address the growing body of evidence that suggests that heterogeneities among blastomeres precede, and possibly inform, their spatial segregation in the embryo. I also discuss whether the origins of such early heterogeneity are stochastic and/or indicative of intrinsic properties of the embryo. Lastly, I argue that the robustness and regulative capacity of preimplantation embryonic development may reflect the existence of multiple converging, if not wholly redundant, mechanisms that act together to generate the necessary diversity of inter-cell-lineage gene expression patterns. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2014 Elektronická adresa http://www.sciencedirect.com/science/article/pii/S1472648313002435
Počet záznamů: 1