Počet záznamů: 1
Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size
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SYSNO ASEP 0425219 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size Tvůrce(i) Shubhra, Q. T. H. (HU)
Kardos, A. F. (HU)
Feczkó, T. (HU)
Macková, Hana (UMCH-V) RID
Horák, Daniel (UMCH-V) RID, ORCID
Tóth, J. (HU)
Dósa, G. (HU)
Gyenis, J. (HU)Zdroj.dok. Journal of Microencapsulation - ISSN 0265-2048
Roč. 31, č. 2 (2014), s. 147-155Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova albumin ; encapsulation ; PLGA (poly d,l-lactic-co-glycolic acid Vědní obor RIV JB - Senzory, čidla, měření a regulace CEP KAN401220801 GA AV ČR - Akademie věd Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000334739200005 EID SCOPUS 84894148393 DOI 10.3109/02652048.2013.814729 Anotace PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA® software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS™/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329 nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion energy (enough sonication time) along with small aqueous/organic volume ratio. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2014
Počet záznamů: 1