Počet záznamů: 1

Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex

SYSNO ASEP	0420970
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex
Tvůrce(i)	Dlouhá, Kateřina (FGU-C) Kagan, Dmytro (FGU-C) Roubalová, Lenka (FGU-C)_{RID, ORCID, SAI} Ujčíková, Hana (FGU-C)_{RID, ORCID} Svoboda, Petr (FGU-C)_{RID, ORCID}
Zdroj.dok.	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 62, č. 5 (2013), s. 547-559
Poč.str.	13 s.
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	GABAB-receptors ; postnatal development ; rat brain cortex ; G-proteins ; Na, K-ATPase
Vědní obor RIV	CE - Biochemie
CEP	GAP207/12/0919 GA ČR - Grantová agentura ČR
	GBP304/12/G069 GA ČR - Grantová agentura ČR
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000327444700009
EID SCOPUS	84888814515
Anotace	GABAB-R1a, GABAB-R1b, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta subunit protein content was determined by quantitative immunoblotting in PM isolated from brain cortex of rats of different ages: between postnatal day1 (PD1) and 90 (PD90). PM density of GABAB-R1alpha, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was high at birth. The intensity of GABAB-R1a and GABAB-R2 subunits signal decreased between the birth and PD15: to 55 % (R1a, ) and 51 % (R2, ), respectively. Contrarily, PM level of the cognate G-proteins Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was unchanged in the course of the whole postnatal period of brain cortex development. Maturation of GABAB-R cascade was substantially different from ontogenetic profile of Na, K-ATPase, which was low at birth and increased between the birth and PD25. In adult rats, membrane content of Na, K-ATPase was 3-times higher than around the birth
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2014

Počet záznamů: 1