Počet záznamů: 1  

Transmembrane adaptor proteins in the high-affinity IgE receptor signaling

  1. 1.
    SYSNO ASEP0399709
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevTransmembrane adaptor proteins in the high-affinity IgE receptor signaling
    Tvůrce(i) Dráber, Petr (UMG-J) RID
    Hálová, Ivana (UMG-J) RID
    Levi-Schaffer, F. (IL)
    Dráberová, Lubica (UMG-J) RID
    Zdroj.dok.Frontiers in Immunology - ISSN 1664-3224
    Roč. 2, 11.1. (2012), s. 95
    Poč.str.11 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovaIgE receptor ; LAT/LAT1 ; LAX ; NTAL/Lab/LAT2 ; PAG/Cbp ; mast cells ; plasma membrane ; transmembrane adaptor proteins
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEP1M0506 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    GA301/09/1826 GA ČR - Grantová agentura ČR
    GAP302/10/1759 GA ČR - Grantová agentura ČR
    KAN200520701 GA AV ČR - Akademie věd
    Institucionální podporaUMG-J - RVO:68378050
    CEZAV0Z50520514 - UMG-J (2005-2011)
    UT WOS000209501200011
    DOI10.3389/fimmu.2011.00095
    AnotaceAggregation of the high-affinity IgE receptor (FcεRI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and de novo synthesis and secretion of cytokines and other compounds. The first biochemically well defined step of this signaling cascade is tyrosine phosphorylation of the FcεRI subunits by Src family kinase Lyn, followed by recruitment and activation of spleen tyrosine kinase (Syk). Activity of Syk is decisive for the formation of multicomponent signaling assemblies, the signalosomes, in the vicinity of the receptors. Formation of the signalosomes is dependent on the presence of transmembrane adaptor proteins (TRAPs). These proteins are characterized by a short extracellular domain, a single transmembrane domain, and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. In mast cells five TRAPs have been identified [linker for activation of T cells (LAT), non-T cell activation linker (NTAL), linker for activation of X cells (LAX), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (PAG), and growth factor receptor-bound protein 2 (Grb2)-binding adaptor protein, transmembrane (GAPT)]; engagement of four of them (LAT, NTAL, LAX, and PAG) in FcεRI signaling has been documented. Here we discuss recent progress in the understanding of how TRAPs affect FcεRI-mediated mast cell signaling. The combined data indicate that individual TRAPs have irreplaceable roles in important signaling events such as calcium response, degranulation, cytokines production, and chemotaxis.
    PracovištěÚstav molekulární genetiky
    KontaktGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2014