Počet záznamů: 1
Mechanistic basis of infertility of mouse intersubspecific hybrids
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SYSNO ASEP 0397570 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mechanistic basis of infertility of mouse intersubspecific hybrids Tvůrce(i) Bhattacharyya, Tanmoy (UMG-J)
Gregorová, Soňa (UMG-J)
Mihola, Ondřej (UMG-J) RID, ORCID
Anger, Martin (UZFG-Y) ORCID
Šebestová, J. (CZ)
Denny, P. (GB)
Šimeček, Petr (UMG-J)
Forejt, Jiří (UMG-J) RID, ORCIDZdroj.dok. Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 110, č. 6 (2013), E468-E477Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova meiosis ; meiotic sex chromosome inactivation ; Prdm9 ; chromosome substitution strains ; Haldane's rule Vědní obor RIV EB - Genetika a molekulární biologie CEP LD11079 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy 1M0520 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GPP305/11/P630 GA ČR - Grantová agentura ČR GA523/09/0743 GA ČR - Grantová agentura ČR Institucionální podpora UMG-J - RVO:68378050 ; UZFG-Y - RVO:67985904 CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000315209800005 DOI 10.1073/pnas.1219126110 Anotace According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than the rest of the genome. Here we propose that asynapsis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the meiotic arrest of interspecific F1 hybrids. We observed extensive asynapsis of chromosomes and disturbance of the sex body in >95% of pachynemas of Mus m. musculus x Mus m. domesticus sterile F1 males. Asynapsis was not preceded by a failure of double-strand break induction, and the rate of meiotic crossing over was not affected in synapsed chromosomes. DNA double-strand break repair was delayed or failed in unsynapsed autosomes, and misexpression of chromosome X and chromosome Y genes was detected in single pachynemas and by genome-wide expression profiling. Oocytes of F1 hybrid females showed the same kind of synaptic problems but with the incidence reduced to half. Most of the oocytes with pachytene asynapsis were eliminated before birth. We propose the heterospecific pairing of homologous chromosomes as a preexisting condition of asynapsis in interspecific hybrids. The asynapsis may represent a universal mechanistic basis of F1 hybrid sterility manifested by pachytene arrest. It is tempting to speculate that a fast-evolving subset of the noncoding genomic sequence important for chromosome pairing and synapsis may be the culprit. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2014 Elektronická adresa http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568299/
Počet záznamů: 1