Počet záznamů: 1
The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice
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SYSNO ASEP 0394829 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice Tvůrce(i) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCID
Páral, P. (CZ)
Savvulidi, F. (CZ)
Šefc, L. (CZ)Celkový počet autorů 7 Zdroj.dok. Purinergic Signalling - ISSN 1573-9538
Roč. 9, č. 2 (2013), s. 207-214Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova ELEVATING EXTRACELLULAR ADENOSINE ; COLONY-STIMULATING FACTOR ; BONE-MARROW Vědní obor RIV BO - Biofyzika CEP GA305/08/0158 GA ČR - Grantová agentura ČR GAP303/11/0128 GA ČR - Grantová agentura ČR OVBIOFYZ20101 GA MO - Ministerstvo obrany Institucionální podpora BFU-R - RVO:68081707 UT WOS 000318559800008 DOI 10.1007/s11302-012-9340-5 Anotace This study continues our earlier findings on the hematopoiesis-modulating effects of adenosine A(1) and A(3) receptor agonists that were performed on committed hematopoietic progenitor and precursor cell populations. In the earlier experiments, N (6)-cyclopentyladenosine (CPA), an adenosine A(1) receptor agonist, was found to inhibit proliferation in the above-mentioned hematopoietic cell systems, whereas N (6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agonist, was found to stimulate it. The topic of this study was to evaluate the possibility that the above-mentioned adenosine receptor agonists modulate the behavior of early hematopoietic progenitor cells and hematopoietic stem cells. Flow cytometric analysis of hematopoietic stem cells in mice was employed, as well as a functional test of hematopoietic stem and progenitor cells (HSPCs). Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2014
Počet záznamů: 1