Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

Jabůrek, Martin; Ježek, Jan; Zelenka, Jaroslav; Ježek, Petr

doi:https://dx.doi.org/10.1016/j.biocel.2013.01.010

Počet záznamů: 1

Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

1.

SYSNO ASEP	0391725
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen
Tvůrce(i)	Jabůrek, Martin (FGU-C)_{ORCID, RID} Ježek, Jan (FGU-C)_{RID, ORCID} Zelenka, Jaroslav (FGU-C)_RID Ježek, Petr (FGU-C)_{RID, ORCID}
Zdroj.dok.	International Journal of Biochemistry and Cell Biology. - : Elsevier - ISSN 1357-2725 Roč. 45, č. 4 (2013), s. 816-825
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	mitochondrial uncoupling protein UCP2 ; mitochondrial phospholipase A(2) isoform gamma ; mitochondrial oxidative stress attenuation ; fatty acid ; antioxidant mechanism
Vědní obor RIV	ED - Fyziologie
CEP	GAP302/10/0346 GA ČR - Grantová agentura ČR
	GPP303/11/P320 GA ČR - Grantová agentura ČR
	ME09018 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	FGU-C - RVO:67985823
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000317371300007
EID SCOPUS	84873700347
DOI	10.1016/j.biocel.2013.01.010
Anotace	Mitochondrial uncoupling protein-2 (UCP2) has been suggested to participate in the attenuation of the reactive oxygen species production, but the mechanism of action and the physiological significance of UCP2 activity remain controversial. Here we tested the hypothesis that UCP2 provides feedback downregulation of oxidative stress in vivo via synergy with an H2O2-activated mitochondrial calcium-independent phospholipase A2 (mt-iPLA2). In this article we demonstarte for the first time that UCP2, functional due to fatty acids released by redox-activated mt-iPLA2gamma, suppresses mitochondrial superoxide production by its uncoupling action. In conclusion, H2O2-activated mt-iPLA2gamma and UCP2 act in concert to protect against oxidative stress
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2014

Počet záznamů: 1