Počet záznamů: 1
Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats
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SYSNO ASEP 0381846 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats Tvůrce(i) Sládek, Martin (FGU-C) RID, ORCID, SAI
Polidarová, Lenka (FGU-C) RID, ORCID
Nováková, Marta (FGU-C)
Parkanová, Daniela (FGU-C)
Sumová, Alena (FGU-C) RID, ORCIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 7, č. 10 (2012), e46951Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova SHR ; circadian system ; clock gene ; metabolism ; colon ; liver ; suprachiasmatic nucleus Vědní obor RIV ED - Fyziologie CEP GAP303/11/0668 GA ČR - Grantová agentura ČR GPP305/10/P244 GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000309452600065 DOI 10.1371/journal.pone.0046951 Anotace The study analyzed the function of the circadian system of Spontaneously hypertensive rat (SHR). The results revealed that SHR exhibited an early chronotype, because the central clock in the suprachiasmaric nuclei of the hypothalamus was phase-advanced relative to light/dark cycle. Moreover, the output rhythm was dampened. The peripheral clocks of SHR reacted to the dampened central clock with tissue-specific consequences. In the colon, the rhythms were severely altered, whereas the effect was only marginal in the liver. These results might result in mutual desynchrony of circadian oscillators within the circadian system of SHR, thereby potentially contributing to metabolic pathology of the rat strain Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2013
Počet záznamů: 1