Počet záznamů: 1  

Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice

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    SYSNO ASEP0380136
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevEffect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice
    Tvůrce(i) Žatecká, Eva (BTO-N)
    Děd, Lukáš (BTO-N) RID
    Elzeinová, Fatima (BTO-N) RID
    Kubátová, Alena (BTO-N) RID
    Dorosh, Andriy (BTO-N) RID
    Margaryan, Hasmik (BTO-N) RID
    Dostálová, Pavla (BTO-N)
    Pěknicová, Jana (BTO-N) RID
    Celkový počet autorů8
    Zdroj.dok.Reproductive Toxicology. - : Elsevier - ISSN 0890-6238
    Roč. 35, č. 1 (2013), s. 32-39
    Poč.str.8 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovatetrabromobisphenol A ; fertility ; reproductive parameters ; spermatogenesis ; histopathology of testes ; apoptosis ; gene expression
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEP2B06151 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    1M06011 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    NS10009 GA MZd - Ministerstvo zdravotnictví
    GA523/09/1793 GA ČR - Grantová agentura ČR
    CEZAV0Z50520701 - BTO-N (2007-2013)
    UT WOS000314003900005
    DOI10.1016/j.reprotox.2012.05.095
    AnotaceTetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA.
    PracovištěBiotechnologický ústav
    KontaktMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Rok sběru2013
Počet záznamů: 1