Počet záznamů: 1
Enhancement of immune response towards non-lipidized Borrelia burgdorferi recombinant OspC antigen by binding onto the surface of metallochelating nanoliposomes with entrapped lipophilic derivatives of norAbuMDP
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SYSNO ASEP 0379796 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Enhancement of immune response towards non-lipidized Borrelia burgdorferi recombinant OspC antigen by binding onto the surface of metallochelating nanoliposomes with entrapped lipophilic derivatives of norAbuMDP Tvůrce(i) Křupka, M. (CZ)
Mašek, J. (CZ)
Bartheldyová, E. (CZ)
Turánek Knotigová, P. (CZ)
Plocková, J. (CZ)
Korvasová, Z. (CZ)
Škrabalová, M. (CZ)
Koudelka, Š. (CZ)
Kulich, P. (CZ)
Zachová, K. (CZ)
Czerneková, L. (CZ)
Strouhal, O. (CZ)
Horynová, M. (CZ)
Šebela, M. (CZ)
Miller, A. D. (GB)
Ledvina, Miroslav (UOCHB-X) RID
Raška, M. (CZ)
Turánek, J. (CZ)Celkový počet autorů 18 Zdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 160, č. 2 (2012), s. 374-381Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Borrelia burgdorferi ; OspC ; metallochelating liposomes ; MDP Vědní obor RIV CC - Organická chemie CEP GAP304/10/1951 GA ČR - Grantová agentura ČR TA01011165 GA TA ČR - Technologická agentura ČR KAN200520703 GA AV ČR - Akademie věd KAN200100801 GA AV ČR - Akademie věd CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000305788800033 DOI 10.1016/j.jconrel.2012.02.017 Anotace Lyme disease caused by spirochete Borrelia burgdorferi sensu lato, is a tick-born illness. If the infection is not eliminated by the host immune system and/or antibiotics, it may further disseminate and cause severe chronic complications. The immune response to Borrelia is mediated by phagocytic cells and by Borrelia-specific complement-activating antibodies associated with Th1 cell activation. A new experimental vaccine was constructed using non-lipidized form of recombinant B. burgdorferi s.s. OspC protein was anchored by metallochelating bond onto the surface of nanoliposomes containing novel nonpyrogenic normuramyglycopeptides modified at carboxy terminus of the peptide part of their molecules by bulky lipophilic acyl residue. After i.d. immunization, the experimental vaccines surpassed Alum with respect to OspC-specific titers of IgG2a, IgG2b isotypes when analog modified with branch fatty acid was used and IgG3, IgM isotypes when analog modified with linear fatty acid was used. Both adjuvants exerted a high adjuvant effect comparable or better than MDP and proved themselves as nonpyrogenic. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2013
Počet záznamů: 1