Počet záznamů: 1
Polymer coatings for delivery of nucleic acid therapeutics
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SYSNO ASEP 0378755 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymer coatings for delivery of nucleic acid therapeutics Tvůrce(i) Laga, Richard (UMCH-V) RID, ORCID
Carlisle, R. (GB)
Tangney, M. (IE)
Ulbrich, Karel (UMCH-V) RID
Seymour, L. W. (GB)Zdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 161, č. 2 (2012), s. 537-553Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova gene delivery ; polymer coating ; viral vectors Vědní obor RIV CD - Makromolekulární chemie CEP IAAX00500803 GA AV ČR - Akademie věd CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000305790300037 DOI 10.1016/j.jconrel.2012.02.013 Anotace Gene delivery remains the greatest challenge for treatment of a broad range of diseases. Combining stability during the delivery phase with activation and transgene expression following arrival at the target site requires sophisticated vectors. Efficient intravenous delivery is the greatest hurdle, with synthetic vectors frequently found to be unstable in the bloodstream, and viral vectors often recognized by both the innate and the adaptive immune system. Both types of vectors benefit from coating with hydrophilic polymers. Self-assembling polyelectrolyte non-viral vectors can achieve both steric and lateral stabilization, endowing them with much improved systemic circulation properties and better access to disseminated targets; similarly viral vectors can be ‘stealthed’ and their physical properties modulated. Both types of vectors may also have their tropism changed following chemical linkage of novel ligands to the polymer coating enabling them site- or cell-specific delivery. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2013
Počet záznamů: 1