Počet záznamů: 1
Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria
- 1.
SYSNO ASEP 0375991 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria Tvůrce(i) Francischetti, I.M.B. (US)
Oliveira, C. J. (BR)
Ostera, G. R. (US)
Yager, S. B. (US)
Debierre-Grockiego, F. (DE)
Carregaro, V. (BR)
Jaramillo-Gutierrez, G. (US)
Hume, J. C. C. (US)
Jiang, L. (US)
Moretz, S. E. (US)
Lin, Ch. K. (US)
Ribeiro, J.M.C. (US)
Long, C. A. (US)
Vickers, B. K. (US)
Schwarz, R. T. (DE)
Seydel, K. B. (US)
Iacobelli, M. (IT)
Ackerman, H. C. (US)
Srinivasan, P. (US)
Gomes, R. B. (US)
Wang, X. (US)
Monteiro, R.Q. (BR)
Kotsyfakis, Michalis (BC-A) RID, ORCID
Sa-Nunes, A. (BR)
Waisberg, M. (US)Zdroj.dok. Arteriosclerosis Thrombosis and Vascular Biology. - : Lippincott Williams & Wilkins - ISSN 1079-5642
Roč. 32, č. 3 (2012), s. 786-798Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova anticoagulants ; blood coagulation ; endothelium ; microcirculation ; vascular biology ; malaria ; defibrotide ; inflammation Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000300639300035 DOI 10.1161/ATVBAHA.111.240291 Anotace The therapeutic use of defibrotide (DF) in malaria is proposed. DF blocks the induction of endothelial tissue factor-mediated coagulation by parasitized red blood cells. At a concentration achievable in vivo, DF suppresses Toll-like receptors 4 and 2 agonist-driven proinflammatory cytokine production by dendritic cells (DCs). We demonstrate that DF directly decreases platelet aggregation and blocks the alternative complement pathway further proposing that DF may act through adenosine receptors. Accordingly, we observe that DF-exposed DCs produce prostaglandin E2 and have enhanced lipopolysaccharide-induced IL-10 secretion. DF blocks parasite invasion of red blood cells and rosetting and the agglutination of parasitized red blood cells. Finally, DF abolishes oocysts development in Anopheles gambiae; in a murine model of cerebral malaria, DF affected parasitemia, decreased IFN-γ levels, and ameliorated clinical score (day 5) with a trend for increased survival. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2013
Počet záznamů: 1