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Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk
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SYSNO ASEP 0373890 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Gene expression variations: potentialities of master regulator polymorphisms in colorectal cancer risk Tvůrce(i) Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Vodička, Pavel (UEM-P ed.) RID
Kumar, R. (DE)Zdroj.dok. Mutagenesis. - : Oxford University Press - ISSN 0267-8357
Roč. 27, č. 2 (2012), s. 161-167Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova master regulators of transcrition ; genome-wide association studies (GWAS) ; colorectal cancer Vědní obor RIV EB - Genetika a molekulární biologie CEP GP305/09/P194 GA ČR - Grantová agentura ČR GAP304/10/1286 GA ČR - Grantová agentura ČR CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000300040200004 DOI 10.1093/mutage/ger057 Anotace Low-penetrance genetic variations contribute significantly to sporadic and familial form of colorectal cancer (CRC). Genome-wide association studies (GWAS) have uncovered numerous robust associations between common variants and CRC risk; only a few of those were protein altering non-synonymous polymorphisms. One of the hypotheses is that non-coding and intergenic variants may change the expression levels of one or several target genes and, thus, account for a fraction of phenotypic differences, including susceptibility to CRC. Such genetic variations have been detected as expression quantitative loci (eQTLs) and defined as “master regulators of transcription”. Hereby we overview the potentialities to use results from GWAS and eQTL Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2013
Počet záznamů: 1