Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
1.
SYSNO ASEP
0370529
Druh ASEP
C - Konferenční příspěvek (mezinárodní konf.)
Zařazení RIV
Záznam nebyl označen do RIV
Název
Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
Tvůrce(i)
Flegel, Martin (UOCHB-X) Flegelová, Z. (CZ) Maloň, Petr (UOCHB-X) Klenerová, V. (CZ) Hynie, S. (CZ)
Celkový počet autorů
5
Zdroj.dok.
Biologically Active Peptides. 12th Conference. - Praha : Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 / Slaninová J.
- ISBN 978-80-86241-44-9
tert-Butylamine was employed as the alternative to piperidine for Fmoc deprotection in liquid and solid phase peptide synthesis. Basic kinetic parameters of deprotecting reaction were checked in chosen Fmoc amino acid derivatives. Solid phase synthesis of cyclic part of oxytocin (tocinamide) was worked out and used for CD spectra measurement.
