Počet záznamů: 1
Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
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SYSNO ASEP 0370115 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses Tvůrce(i) Pata, S. (TH)
Otáhal, Pavel (UMG-J) RID
Brdička, Tomáš (UMG-J) RID
Laopajon, W. (TH)
Mahasongkram, K. (TH)
Kasinrer, W. (TH)Zdroj.dok. BMC Research Notes. - : Springer - ISSN 1756-0500
Roč. 4, - (2011), s. 293Poč.str. 13 s. Forma vydání http://www.biomedcentral.com/1756-0500/4/293 - http://www.biomedcentral.com/1756-0500/4/293 Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova CD99 ; MHC II ; CD81 Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) DOI 10.1186/1756-0500-4-293 Anotace We analyzed the association of CD99 with other cell surface molecules involved in T cell activation. We demonstrate the association of MHC class I, MHC class II and tetraspanin CD81 with CD99 molecules on the cell surface. Association of CD99 with its partners was observed for both isoforms. In addition, we determined that CD99 is a lipid raft-associated membrane protein and is recruited into the immunologic synapse during T cell activation. The implication of CD99 on T cell activation was investigated. Inhibition of anti-CD3 induced T cell proliferation by an anti-CD99 monoclonal antibody was observed. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
Počet záznamů: 1