Počet záznamů: 1
In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism
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SYSNO ASEP 0368606 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism Tvůrce(i) Siller, M. (CZ)
Anzenbacher, P. (CZ)
Anzenbacherová, E. (CZ)
Doležal, Karel (UEB-Q) RID, ORCID
Strnad, Miroslav (UEB-Q) RID, ORCIDCelkový počet autorů 5 Zdroj.dok. Xenobiotica. - : Taylor & Francis - ISSN 0049-8254
Roč. 41, č. 11 (2011), s. 934-944Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova DRUG-DRUG INTERACTIONS ; SUBSTRATE-SPECIFICITY ; R-ROSCOVITINE ; GLUCURONIDATION ; CELLS Vědní obor RIV EF - Botanika CEP GA301/08/1649 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000295618400002 DOI 10.3109/00498254.2011.593209 Anotace 1. Neutrophil growth factors (NGFs) stimulate neutrophil growth and survival. The first synthetic cytokinin-derived NGF was recently discovered and is a prospective drug owing to its potential use in anti-inflammatory therapy. The metabolism of some cytokinin-derived drugs (e.g. R-roscovitine, olomoucine II) has already been studied and it has been shown that they may give rise to drug-drug interactions. 2. In this in vitro study, the interactions of the novel neutrophil growth factor NGF1568 with two of the main classes of human drug-metabolizing enzymes, cytochromes P450 (CYPs) and UDP-glucuronosyltransferases (UGTs), were tested. Of the CYPs evaluated, NGF1568 was found to inhibit only CYP2C9, by an uncompetitive mechanism and with a K(i) value of 349 mu M. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2012
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