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Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway
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SYSNO ASEP 0368414 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway Tvůrce(i) Seki, T. (GB)
Carroll, F. (GB)
Illingworth, S. (GB)
Green, N. (GB)
Cawood, R. (GB)
Bachtarzi, H. (GB)
Šubr, Vladimír (UMCH-V) RID, ORCID
Fisher, K. D. (GB)
Seymour, L. W. (GB)Zdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 156, č. 3 (2011), s. 381-389Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova drug delivery ; adenovirus ; vascular permeability Vědní obor RIV CD - Makromolekulární chemie CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000298555000014 DOI 10.1016/j.jconrel.2011.08.022 Anotace Tumour Necrosis Factor alpha (TNF) is a cytokine with known vascular permeabilising activity. It is employed during isolated limb perfusion to enhance delivery of chemotherapeutic drugs into tumour tissue. The use of lytic viruses provides a new approach to cancer treatment that is limited by the low efficiency of extravasation of viral particles into tumours. TNF enhances the delivery of virus particles through the endothelial layer to tumour cells in vitro and in vivo. Intravenous administration of TNF resulted in a 3- to 6-fold increase in EL4 tumour uptake of Evans Blue/Albumin, adenovirus and long-circulating polymer coated adenovirus. Endothelial permeabilisation could be suppressed in vitro and in vivo by Y-27632, a Rho kinase inhibitor, without inhibiting viral infection. TNF enhances the delivery of virus particles into tumours through a Rho A/Rho kinase dependent mechanism and may be a new strategy for increasing the delivery of oncolytic viruses and other therapeutic agents. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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