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Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair
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SYSNO ASEP 0368381 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair Tvůrce(i) Kubinová, Šárka (UEM-P) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCID
Hejčl, Aleš (UEM-P) RID, ORCID
Plichta, Zdeněk (UMCH-V)
Kotek, Jiří (UMCH-V) RID
Syková, Eva (UEM-P) RIDZdroj.dok. Journal of Biomedical Materials Research. Part A. - : Wiley - ISSN 1549-3296
Roč. 99, č. 4 (2011), s. 618-629Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova 2-hydroxyethyl methacrylate ; scaffold ; spinal cord repair Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP IAA500390902 GA AV ČR - Akademie věd GAP304/11/0731 GA ČR - Grantová agentura ČR GPP304/11/P633 GA ČR - Grantová agentura ČR CEZ AV0Z50390703 - UEM-P (2007-2013) AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000297019200012 DOI 10.1002/jbm.a.33221 Anotace Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2012
Počet záznamů: 1