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Determination of Oxygen Radical Absorbance Capacity of Black Cumin (Nigella sativa) Seed Quinone Compounds
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SYSNO ASEP 0367700 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Determination of Oxygen Radical Absorbance Capacity of Black Cumin (Nigella sativa) Seed Quinone Compounds Tvůrce(i) Tesařová, H. (CZ)
Svobodová, B. (CZ)
Kokoška, L. (CZ)
Maršík, Petr (UEB-Q) RID, ORCID
Přibylová, Marie (UEB-Q)
Landa, Přemysl (UEB-Q) RID, ORCID
Vadlejch, J. (CZ)Zdroj.dok. Natural Product Communications - ISSN 1934-578X
Roč. 6, č. 2 (2011), s. 213-216Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Antioxidative activity ; Dihydrothymoquinone ; Thymoquinone Vědní obor RIV GM - Potravinářství CEP GA525/08/1179 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000287613800014 Anotace In this study, the antioxidant capacities of main quinone constituents of Nigella saliva seeds, namely dithymoquinone (1), thymohydroquinone (2) and thymoquinone (3), were compared using DPPH and ORAC methods. The best scavenging activity was produced by 2, which showed a remarkable activity of 2.60 Trolox equivalents (TE) in a concentration range between 1.6 and 6.4 mu g/mL and IC50 value of 2.4 mu g/mL, in ORAC and DPPH assays, respectively. Contrastingly, 3 possessed only weak DPPH scavenging efficacy (IC50 = 170 mu g/mL) but significant antioxidative action of 1.91 TE in ORAC assay. No effect has been observed for 1. Additionally, modified protocol for synthesis of 2 has been developed with aim to enhance its availability for further studies as well as for its future potential use. Based on the results of this study, we conclude that 2 could be considered as a compound with prospective antioxidative properties. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2012
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