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Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
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SYSNO ASEP 0367669 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission? Tvůrce(i) Olabarria, M. (GB)
Noristani, H. N. (GB)
Verkhratsky, Alexei (UEM-P)
Rodríguez Arellano, Jose Julio (UEM-P)Zdroj.dok. Molecular Neurodegeneration
Roč. 6, č. 1 (2011), s. 55-63Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova astroglia ; glutamine synthetase ; Alzheimer?'?s disease Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP GA309/09/1696 GA ČR - Grantová agentura ČR GAP304/11/0184 GA ČR - Grantová agentura ČR GA305/08/1384 GA ČR - Grantová agentura ČR GA309/08/1381 GA ČR - Grantová agentura ČR CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000294536400001 EID SCOPUS 79960887452 DOI 10.1186/1750-1326-6-55 Anotace Here, we report a decline in astrocytic glutamine synthetase (GS) in two major cognitive areas of the hippocampus (the dentate gyrus, DG and the CA1) in 3xTg-AD animals) aged between 9 and 18 months. Such a decrease in astrocytic GS is directly associated with the presence of Aβ deposits indicating AD-related impairments of glutamate homeostatic system, at the advanced and late stages of the disease, which may affect the efficacy of glutamatergic transmission in the diseased brain that may contribute to the cognitive deficiency. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2012
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