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Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly
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SYSNO ASEP 0366666 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly Tvůrce(i) Breton, M. (FR)
Berret, J. - F. (FR)
Bourgaux, C. (FR)
Kral, Teresa (UFCH-W) RID, ORCID
Hof, Martin (UFCH-W) RID, ORCID
Pichon, Ch. (FR)
Bessodes, M. (FR)
Scherman, D. (FR)
Mignet, N. (FR)Zdroj.dok. Langmuir. - : American Chemical Society - ISSN 0743-7463
Roč. 27, č. 20 (2011), s. 12336-12345Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova fluorescence correlation spectroscopy ; angle neutron-scattering ; bilayer thickness Vědní obor RIV CF - Fyzikální chemie a teoretická chemie CEP IAA400400621 GA AV ČR - Akademie věd LC06063 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000295665400013 DOI 10.1021/la202439s Anotace We assessed in this work how a chemical structure difference could influence a supramolecular organization and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical difference was situated on their hydrophilic part which was either a pure neutral thiourea head or a mixture of three thiourea function derivatives, thiourea, iminothiol, and charged iminothiol. This small difference was obtained thanks to the last chemical deprotection conditions of the polar head hydroxyl groups. Light, neutron, and X-ray scattering techniques have been used to investigate the spatial structure of the liposomes and lipoplexes formed by the lipids. The chemical structure difference impacts the supramolecular assemblies of the lipids and with DNA as shown by fluorescence correlation spectroscopy (FCS), X-ray, and neutron scattering. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2012
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