Počet záznamů: 1

Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

SYSNO ASEP	0366420
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light
Tvůrce(i)	Nováková, Marta (FGU-C) Polidarová, Lenka (FGU-C)_{RID, ORCID} Sládek, Martin (FGU-C)_{RID, ORCID, SAI} Sumová, Alena (FGU-C)_{RID, ORCID}
Zdroj.dok.	Neuroscience. - : Elsevier - ISSN 0306-4522 Roč. 197, - (2011), s. 65-71
Poč.str.	7 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	circadian system ; suprachiasmatic nucleus ; restricted feeding ; constant light
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
CEP	GA305/09/0321 GA ČR - Grantová agentura ČR
	GAP303/11/0668 GA ČR - Grantová agentura ČR
	LC554 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000297140700007
DOI	10.1016/j.neuroscience.2011.09.028
Anotace	The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erbα and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2012

Počet záznamů: 1