Počet záznamů: 1
Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic
- 1.
SYSNO ASEP 0365854 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic Tvůrce(i) Rössner ml., Pavel (UEM-P) RID, ORCID
Uhlířová, Kateřina (UEM-P)
Beskid, Olena (UEM-P)
Rössnerová, Andrea (UEM-P) RID
Švecová, Vlasta (UEM-P) RID
Šrám, Radim (UEM-P) RIDZdroj.dok. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 713, 1-2 (2011), s. 76-82Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova oxidative stress ; chromosomal aberrations ; gene expression Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP SP/1B3/8/08 GA MŽP - Ministerstvo životního prostředí 2B08005 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000293930400009 EID SCOPUS 79960210999 DOI 10.1016/j.mrfmmm.2011.06.001 Anotace The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2012
Počet záznamů: 1