Počet záznamů: 1
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
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SYSNO ASEP 0365459 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Tvůrce(i) Dráberová, Eduarda (UMG-J) RID, ORCID
Vinopal, Stanislav (UMG-J)
Morfini, G. (US)
Liu, P. S. (US)
Sládková, Vladimíra (UMG-J)
Sulimenko, Tetyana (UMG-J)
Burns, M.R. (US)
Solowska, J. (US)
Kulandaivel, K. (US)
De Chadarévian, J.P. (US)
Legido, A. (US)
Mork, S.J. (US)
Janáček, Jiří (FGU-C) RID, ORCID
Baas, P. (US)
Dráber, Pavel (UMG-J) RID, ORCID
Katsetos, C.D. (US)Celkový počet autorů 16 Zdroj.dok. Journal of Neuropathology and Experimental Neurology - ISSN 0022-3069
Roč. 70, č. 9 (2011), s. 811-826Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova spastin ; glioblastoma ; cell motility Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP302/10/1701 GA ČR - Grantová agentura ČR GA204/09/1777 GA ČR - Grantová agentura ČR GD204/09/H084 GA ČR - Grantová agentura ČR KAN200520701 GA AV ČR - Akademie věd LC545 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294247700008 DOI 10.1097/NEN.0b013e31822c256d Anotace This research article is first report of the role of spastin in cell motility. The enzyme spastin is from microtubule-severing ATPases and regulates lenght of microtubules. Among strategies used for treating malignant tumors belongs disrupting the integrity of microtubules. The role of microtubules on invasivity has the higher propensity especially in glioblastoma cells from brain. To find the answer to question, if spastin and microtubules regulation somehow influence each other, spastin expression evaluation and testing of intracellular distribution was performed in human glioblastomas and astrocytes. It was found that spastin expression is increased in tumor cells. Surprisingly, functional experiments comparing the effects of spastin depletion on the motility and proliferation in glioblastomas have shown decreased motility and higher proliferation rate. The article proposes that spastin in glioblastomas might be linked to tumor cell invasion. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
Počet záznamů: 1