Počet záznamů: 1
Association between Va166Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients
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SYSNO ASEP 0364541 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Association between Va166Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients Tvůrce(i) Šerý, Omar (UZFG-Y) RID
Šťastný, F. (CZ)
Zvolský, P. (CZ)
Hlinomazová, Z. (CZ)
Balcar, V. J. (AU)Celkový počet autorů 5 Zdroj.dok. Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 499, č. 3 (2011), s. 154-157Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova Glutamate ; GABA ; Retina Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000294087800003 DOI 10.1016/j.neulet.2011.05.038 Anotace Brain-derived neurotrophic factor (BDNF) is a protein encoded, in humans, by BDNF gene on chromosome U. BDNF protects adult neurons and promotes growth and differentiation during ontogenetic development but the nature and magnitude of its effects could be influenced by functional polymorphisms. The BDNF polymorphism Va166Met (rs6265) has been studied in the context of etiology of mental diseases including alcoholism. Alcoholism - a complex disorder known to be linked to several genes - has multiple manifestations, including sensory deficits such as those affecting vision. In the present study we examined a relationship between the Va166Met polymorphism, alcohol dependence and colour vision deficiency (CVD) in 167 alcohol-dependent men and 289 control male subjects. Statistical analysis revealed that almost half (about 48%) of the alcohol dependent men had a CVD. In addition we found that CVD was significantly associated (P = 0.005) with the Va166Met polymorphism. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2012
Počet záznamů: 1