Počet záznamů: 1
Altered neural and vascular mechanisms in hypertension
- 1.
SYSNO ASEP 0364294 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Altered neural and vascular mechanisms in hypertension Tvůrce(i) Pintérová, Mária (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAIZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 60, č. 3 (2011), s. 381-402Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova adrenoceptors ; G proteins ; L-type voltage-dependent calcium channels ; potassium channels ; RhoA/Rho kinase ; genetic hypertension Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie CEP GA305/09/0336 GA ČR - Grantová agentura ČR CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000293138600002 Anotace This review is focused on two major antagonistic players in the regulation of blood pressure, i.e. sympathetic nervous system (by stimulation of adrenoceptors coupled to stimulatory and inhibitory G proteins) and nitric oxide (by cGMP signaling pathway), elicit their actions via the control of calcium influx through L-VDCC. However, L-type calcium current can also be regulated by the changes in membrane potential elicited by the activation of potassium channels, the impaired function of which was detected in hypertensive animals. The dominant role of enhanced calcium influx in the pathogenesis of high blood pressure of genetically hypertensive animals is confirmed not only by therapeutic efficacy of calcium antagonists but especially by the absence of hypertension in animals in which L-type calcium current was diminished by pertussis toxin-induced inactivation of inhibitory G proteins Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2012
Počet záznamů: 1