Počet záznamů: 1

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells

SYSNO ASEP	0359477
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells
Tvůrce(i)	Šolc, Petr (UZFG-Y)_{RID, ORCID} Schultz, R. M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID}
Zdroj.dok.	Molecular Human Reproduction - ISSN 1360-9947 Roč. 16, č. 9 (2010), s. 654-664
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	resumption of meiosis ; prophase I arrest ; oocyte
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GC301/09/J036 GA ČR - Grantová agentura ČR
	ME08030 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
UT WOS	000281535400006
DOI	10.1093/molehr/gaq034
Anotace	Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly coupled with regulating cyclin-dependent kinase 1 (CDK1) activity. Prophase I arrest depends on inhibitory phosphorylation of CDK1 and anaphase-promoting complex-(APC-CDH1)-mediated regulation of cyclin B levels. Prophase I arrest is maintained by endogenously produced cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) that in turn phosphorylates (and activates) the nuclear kinase WEE2. In addition, PKA-mediated phosphorylation of the phosphatase CDC25B results in its cytoplasmic retention. The combined effect maintains low levels of CDK1 activity that are not sufficient to initiate resumption of meiosis.
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2012

Počet záznamů: 1