Počet záznamů: 1

Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections

SYSNO ASEP	0359447
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections
Tvůrce(i)	Kváč, Martin (BC-A)_{RID, RID, ORCID} Lӧvy, Alena (BC-A)_RID Sak, Bohumil (BC-A)_{RID, ORCID} Květoňová, Dana (BC-A)_SAI Jalovecká, M. (CZ) Rost, M. (CZ) Salát, Jiří (BC-A)_{RID, ORCID}
Zdroj.dok.	Parasite immunology. - : Wiley - ISSN 0141-9838 Roč. 33, č. 4 (2011), 210-216
Poč.str.	7 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	CD4+T-lymphocytes ; CD8+T-lymphocytes ; Cryptosporidium muris ; T-cell-mediated immunity
Vědní obor RIV	EC - Imunologie
CEP	KJB500960701 GA AV ČR - Akademie věd
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000288249400002
DOI	10.1111/j.1365-3024.2010.01271.x
Anotace	The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2012

Počet záznamů: 1