Počet záznamů: 1
The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties
- 1.
SYSNO ASEP 0359317 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties Tvůrce(i) Holčáková, J. (CZ)
Tomašec, P. (CZ)
Burget, J. J. (GB)
Wang, E. C. Y. (GB)
Wilkinson, G. W. G. (GB)
Hrstka, R. (CZ)
Kryštof, Vladimír (UEB-Q) RID, ORCID
Strnad, Miroslav (UEB-Q) RID, ORCID
Vojtešek, B. (CZ)Zdroj.dok. Antiviral Chemistry and Chemotherapy. - : International Medical Press - ISSN 0956-3202
Roč. 20, č. 3 (2010), s. 133-142Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Cyclin-dependent Kinase ; Olomoucine II ; vaccinia Vědní obor RIV EE - Mikrobiologie, virologie CEP GA301/08/1649 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) DOI 10.3851/IMP1460 Anotace Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent. Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2011
Počet záznamů: 1