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Quantification in MALDI-TOF mass spectrometry of modified polymers
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SYSNO ASEP 0359037 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Quantification in MALDI-TOF mass spectrometry of modified polymers Tvůrce(i) Walterová, Zuzana (UMCH-V)
Horský, Jiří (UMCH-V) RID, ORCIDZdroj.dok. Analytica Chimica Acta. - : Elsevier - ISSN 0003-2670
Roč. 693, 1/2 (2011), s. 82-88Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova MALDI-TOF mass spectrometry ; modified polymers ; quantification Vědní obor RIV CC - Organická chemie CEP GA203/08/0543 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000290886800010 DOI 10.1016/j.aca.2011.03.019 Anotace MALDI-TOF MS quantification is hampered by the poor reproducibility and molecular-mass and compositional discrimination. The use of an internal standard increases reproducibility and allows a calibration curve to be constructed. With synthetic polymers, the method requires a polymer of the same molecular mass distribution and composition as the analyte. When the content of the precursor polymer in a modified polymer is sought, the pure precursor is usually available and the modified polymer can serve as an internal standard. The method has to be combined with that of standard addition and the precursor polymer added directly to the sample. The experiments with simulated modified polymers revealed the signal-intensity ratio not proportional to the concentrations ratio. Thus, the basic assumption of the standard-addition method is not met. Therefore, the multi-point combined internal-standard standard-addition method based on the power-type calibration curve was developed and verified. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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