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Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery
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SYSNO ASEP 0358505 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery Tvůrce(i) Angelova, A. (FR)
Angelov, Borislav (UMCH-V) RID
Mutafchieva, R. (BG)
Lesieur, S. (FR)
Couvreur, P. (FR)Zdroj.dok. Accounts of Chemical Research. - : American Chemical Society - ISSN 0001-4842
Roč. 44, č. 2 (2011), s. 147-156Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova lipid-water phases ; liquid crystals ; multicompartment lipid nanostructures Vědní obor RIV CF - Fyzikální chemie a teoretická chemie CEP GA202/09/2078 GA ČR - Grantová agentura ČR GAP208/10/1600 GA ČR - Grantová agentura ČR CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000287263700007 DOI 10.1021/ar100120v Anotace Lipids and lipopolymers self-assembled into biocompatible nano and mesostructured functional materials offer many potential applications in medicine and diagnostics. In this Account, it is demonstrated how high-resolution structural investigations of bicontinuous cubic templates made from lyotropic thermosensitive liquid-crystalline (LC) materials have initiated the development of innovative lipidopolymeric self-assembled nanocarriers. Such structures have tunable nanochannel sizes, morphologies, and hierarchical inner organizations and provide potential vehicles for the predictable loading and release of therapeutic proteins, peptides, or nucleic acids. This Account shows that structural studies of swelling of bicontinuous cubic lipid/water phases are essential for overcoming the nanoscale constraints for encapsulation of large therapeutic molecules in multicompartment lipid carriers. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2012
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